Circulating Soluble Receptor for Advanced Glycation End Products Is Inversely Associated with Glycemic Control and S100A12 Protein
نویسندگان
چکیده
منابع مشابه
Advanced glycation end products, soluble receptor for advanced glycation end products, and risk of colorectal cancer.
BACKGROUND Advanced glycation end products (AGE) accumulate in human tissue proteins during aging, particularly under hyperglycemia conditions. AGEs induce oxidative stress and inflammation via the receptor for AGEs (RAGE) and soluble RAGE (sRAGE) can neutralize the effects mediated by RAGE-ligand engagement. METHODS We examined the association between N(ε)-(carboxymethyl)lysine (CML), a prom...
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Objectives Membrane bound receptor for advanced glycation end products (RAGE) is over-expressed in response to increasing concentrations of its ligand (eg S100A12) and triggers an inflammatory immune response. Its truncated form sRAGE acts as decoy receptor and competes for ligands thus down-modulating inflammation. Decreased sRAGE levels are associated with rheumatoid arthritis, Sjogren syndro...
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The soluble receptor for advanced glycation end-products (sRAGE) has anti-inflammatory properties, and deficiency of circulating sRAGE is associated with various human diseases. Whether sRAGE concentrations are reduced in chronic obstructive pulmonary disease (COPD) has not been determined. The aim of this study was to determine plasma levels of sRAGE in COPD patients and establish whether sRAG...
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OBJECTIVE To determine the association between circulating soluble receptor for advanced glycation end products (sRAGE) and coronary atherosclerosis. RESEARCH DESIGN AND METHODS Using data from the Dallas Heart Study, a probability-based population sample, the association between plasma levels of sRAGE and coronary artery calcium (CAC) was assessed among 2,571 subjects with complete imaging a...
متن کاملSerum Adiponectin, Resistin, and Circulating Soluble Receptor for Advanced Glycation End Products in Colectomy Patients
AIM Surgical trauma and associated complications are frequently related to physiological stress during colectomy. This study evaluated the response of adiponectin, resistin, and circulating soluble receptor for advanced glycation end products (sRAGE) in colectomy patients with or without an enhanced recovery protocol. METHOD Serum samples were collected from 44 colectomy patients at 3 timfram...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2006
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2005-2559